期刊
DEVELOPMENTAL CELL
卷 38, 期 6, 页码 643-655出版社
CELL PRESS
DOI: 10.1016/j.devcel.2016.08.011
关键词
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资金
- Howard Hughes Medical Institute
- California Institute for Regenerative Medicine
- Fannie and John Hertz Foundation
- U.S. National Science Foundation
- Davidson Institute for Talent Development
- MacGillavry fellowship from University of Amsterdam
- Dutch Cancer Society [2013-6057]
- NWO ALW VIDI grant [864.13.002]
There were multiple prerequisites to the evolution of multicellular animal life, including the generation of multiple cell fates (cellular diversity) and their patterned spatial arrangement (spatial form). Wnt proteins operate as primordial symmetry-breaking signals. By virtue of their short-range nature and their capacity to activate both lineage-specifying and cell-polarizing intracellular signaling cascades, Wnts can polarize cells at their site of contact, orienting the axis of cell division while simultaneously programming daughter cells to adopt diverging fates in a spatially stereotyped way. By coupling cell fate to position, symmetry breaking Wnt signals were pivotal in constructing the metazoan body by generating cellular diversity and spatial form.
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