期刊
EUROPEAN HEART JOURNAL
卷 42, 期 22, 页码 2170-2185出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehaa1050
关键词
Chronic kidney disease; Cardiovascular disease; Lipoproteins; Low-density lipoprotein; High-density lipoprotein; Triglycerides; Atherosclerosis; Lipid-lowering therapy
资金
- Deutsche Forschungsgemeinschaft [DFG SFB/TRR 219, 322900939]
- European Uremic Toxin (EUTOX)
- Swiss National Science Foundation
- Swiss Heart Foundation
- European Uremic Toxin (EUTOX) work group of the ESAO
- ERA-EDTA
CKD patients have a specific lipoprotein pattern termed 'uraemic dyslipidaemia', which plays a role in the pathogenesis of CKD-associated cardiovascular diseases. Uraemia leads to various modifications of lipoprotein structure, affecting their functionality.
Chronic kidney disease (CKD) is associated with high cardiovascular risk. CKD patients exhibit a specific lipoprotein pattern termed 'uraemic dyslipidaemia', which is characterized by rather normal tow-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, and high triglyceride plasma levels. All three lipoprotein classes are involved in the pathogenesis of CKD-associated cardiovascular diseases (CVDs). Uraemia leads to several modifications of the structure of lipoproteins such as changes of the proteome and the lipidome, post-translational protein modifications (e.g. carbamytation) and accumulation of small-molecular substances within the lipoprotein moieties, which affect their functionality. Lipoproteins from CKD patients interfere with lipid transport and promote inflammation, oxidative stress, endothelial dysfunction as well as other features of atherogenesis, thus contributing to the development of CKD-associated CVD. While, lipid-modifying therapies play an important rote in the management of CKD patients, their efficacy is modulated by kidney function. Novel therapeutic agents to prevent the adverse remodelling of lipoproteins in CKD and to improve their functional properties are highly desirable and partially under development. [GRAPHICS] .
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