期刊
DEVELOPMENTAL CELL
卷 38, 期 6, 页码 601-609出版社
CELL PRESS
DOI: 10.1016/j.devcel.2016.08.010
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资金
- Wellcome Trust
- Medical Research Council
- BBSRC [BB/M007219/1] Funding Source: UKRI
- MRC [MC_PC_12026] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M007219/1] Funding Source: researchfish
- Medical Research Council [MC_PC_12026] Funding Source: researchfish
Mammalian epidermis is maintained through proliferation of stem cells and differentiation of their progeny. The balance between self-renewal and differentiation is controlled by a variety of interacting intrinsic and extrinsic factors. Although the nature of these interactions is complex, they can be modeled in a reductionist fashion by capturing single epidermal stem cells on micropatterned substrates and exposing them to individual stimuli, alone or in combination, over defined time points. These studies have shown that different extrinsic stimuli trigger a common outcome initiation of terminal differentiation by activating different signaling pathways and eliciting different transcriptional responses.
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