期刊
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
卷 62, 期 1, 页码 29-38出版社
WILEY
DOI: 10.1002/em.22415
关键词
DNA sequencing; Escherichia coli CC strains; mutagenicity
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [301952/2005-1]
Flavonoids from Brazilian pepper tree stem bark show mutagenic potential, possibly inducing mutations due to oxidative damage. Some medicinal plant flavonoids may have oxidative and toxic effects, requiring further investigation.
Flavonoids are a diverse family of plant compounds that are involved in pigmentation, protection, and endogenous regulation. Flavonoids also have medicinal applications, suggesting that they may exert chemoprotective effects. However, some studies have shown, that some plant flavonoids have oxidative and toxic effects, including those produced by Schinus terebinthifolius. In Brazil, extracts of this plant are widely used for medical purposes. In this study, we analyzed the mutagenic potential of two flavonoid-enriched fractions from Brazilian pepper tree stem bark using Escherichia coli CC strains deficient and proficient in enzymes involved in the DNA repair of oxidative lesions. The highest mutagenic response was detected in the CC104mutMmutY strain but CC104mutY showed a higher mutation frequency than CC104mutM. The spectrum of mutations induced in plasmid DNA is composed of mutations typically caused by oxidative lesions. However, a new type of lesion must be occurred to explain the cytotoxicity, higher mutation rates in the CC104mutY strain, and the rare A:T -> T:A and G:C -> C:G transversions found in this work.
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