期刊
ENVIRONMENT INTERNATIONAL
卷 146, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2020.106296
关键词
Polybrominated diphenyl ethers; Neurodevelopment; Cognitive ability; Pregnancy cohort
资金
- Chemicals Management Plan of Health Canada
- Canadian Institute of Health Research [MOP -81285]
- Ontario Ministry of the Environment - Chemicals Management Plan of Health Canada
- Social Science and Humanities Research Council of Canada (SSHRC)
- Fonds de recherche du Quebec Societe et culture (FRQSC)
- Fonds de recherche du Quebec -Sante (FRQS)
The study found that prenatal exposure to background levels of PBDEs, especially BDE-47, was associated with lower IQ scores in boys, but not in girls. This suggests that exposure to PBDEs during early development may have a sex-dependent and detrimental effect on a child's neurodevelopmental trajectory.
Background: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with adverse neurodevelopmental outcomes in children, but evidence remains mixed regarding sex differences in this association. Objective: To examine the prospective association between prenatal PBDE exposure and cognitive ability in young children, as well as potential sex differences. Methods: The study was conducted in a multi-site Canadian pregnancy cohort recruited in 2008-11. PBDEs were measured in maternal plasma samples collected early in pregnancy. Cognitive ability was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) in children at age 3 years (mean = 3.4). Multiple linear regression was used to analyze the association between maternal PBDE plasma concentrations (lipid-standardized and log10-transformed) and Verbal, Performance, and Full Scale IQ scores on the whole sample and stratified by sex, adjusting for confounders. Results: The sample was composed of 592 children (291 boys and 301 girls). A tenfold increase in maternal blood PBDE concentration (sum of BDE-47, -99, -100, and -153) was associated with lower Full Scale scores in boys (-3.4 points; 95% CI: -7.0, 0.1), after adjusting for confounders. BDE-47 was the congener with the highest concentrations in maternal blood and a tenfold increase in exposure was associated with significantly lower Full Scale IQ scores in boys (-4.4 points; 95% CI: -7.9, -0.9), after adjusting for confounders. Verbal and Performance IQ scores were similarly associated with PBDE exposure. Maternal blood PBDE concentrations were not associated with IQ scores in girls. Conclusions: Prenatal exposure to background levels of PBDEs, especially BDE-47, was associated with lower IQ scores in boys, but not in girls. Our results support that exposure to PBDEs during early development may be sex-dependent and detrimental to a child's neurodevelopmental trajectory.
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