期刊
DEVELOPMENTAL BIOLOGY
卷 420, 期 2, 页码 239-250出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2016.08.010
关键词
Adult stem cell; Organoid; Development; Gut; Stomach; Small intestine; Colon
资金
- European Research Council [1570398.99]
- Hector Foundation [M65.2]
- Wilhelm Sander Foundation [2014.104.1]
- German Cancer Aid [111350]
- Medical Faculty Carl Gustav Carus Dresden at the Technical University Dresden [60.367]
The gastrointestinal tract is characterized by a self-renewing epithelium fueled by adult stem cells residing at the bottom of the intestinal crypt and gastric glands. Their activity and proliferation is strongly dependent on complex signaling pathways involving other crypt/gland cells as well as surrounding stromal cells. In recent years organoids are becoming increasingly popular as a new and powerful tool to study developmental or other biological processes. Organoids retain morphological and molecular patterns of the tissue they are derived from, are self-organizing, relatively simple to handle and accessible to genetic engineering. This review focuses on the developmental processes and signaling molecules involved in epithelial homeostasis and how a profound knowledge of these mechanisms allowed the establishment of a three dimensional organoid culture derived from adult gastrointestinal stem cells. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据