期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 57, 期 -, 页码 75-87出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2015.12.017
关键词
Flagellin; Yersinia ruckeri; Rainbow trout; Cytokine; Acute phase protein; Antimicrobial peptide
资金
- Ministry of Science and Technology of Thailand
- Mahasarakham University
- MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland) - Scottish Funding Council [HR09011]
- European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union [311993 TARGETFISH]
Flagellin is the principal component of bacterial flagellum and a major target of the host immune system. To provide new insights into the role of flagellin in fish immune responses to flagellated microorganisms, a recombinant flagellin from Yersinia ruckeri (rYRF) was produced and its bioactivity investigated in the trout macrophage cell line RTS-11 and head kidney cells. rYRF is a potent activator of pro-inflammatory cytokines, acute phase proteins, antimicrobial peptides and subunits of the IL-12 cytokine family. This and the synergy seen with IFN-gamma to enhance further expression of specific IL-12 and TNF-alpha isoforms may suggest that flagellin could be a useful immune stimulant or adjuvant for use in aquaculture. Gene paralogues were often differentially modulated, highlighting the need to study all of the paralogues of immune genes in fish to gain a full understanding of the effects of PAMPs or other stimulants, and the potential immune responses elicited. (C) 2015 Elsevier Ltd. All rights reserved.
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