期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 54, 期 1, 页码 137-144出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2015.09.008
关键词
Adaptive immunity; RNA-seq; Gasterosteus aculeatus; Diplostomum pseudospathaceum; Parasite; Transcriptomics
资金
- Deutsche Forschungsgemeinschaft (DFG) [SPP 1399, RE 1108/13-2, RE 1108/13-1]
- GEOMAR Helmholtz Centre for Ocean Research Kiel
- Max Planck Institute for Evolutionary Biology
Adaptive immunity in vertebrates can confer increased resistance against invading pathogens upon reinfection. But how specific parasite genotypes affect the temporal transition from innate to adaptive immunity under continual exposure to parasites is poorly understood. Here, we investigated the effects of homologous and heterologous exposures of genetically distinct parasite lineages of the eye fluke Diplostomum pseudospathaceum on gene expression patterns of adaptive immunity in sticklebacks (Gasterosteus aculeatus). Observable differences in gene expression were largely attributable to final exposures while there was no transcription pattern characteristic for a general response to repeated infections with D. pseudospathaceum. None of the final exposure treatments was able to erase the distinct expression patterns resulting from a heterologous pre-exposed fish. Interestingly, heterologous final exposures showed similarities between different treatment groups subjected to homologous pre-exposure. The observed pattern was supported by parasite infection rates and suggests that host immunization was optimized towards an adaptive immune response that favored effectiveness against parasite diversity over specificity. (C) 2015 Elsevier Ltd. All rights reserved.
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