期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 55, 期 -, 页码 12-20出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2015.10.002
关键词
Serum amyloid P component; Cynoglossus semilaevis; Innate immunity; Antibacterial; Antiviral
资金
- National Basic Research Program of China [2012CB114406]
- Taishan Scholar Program of Shandong Province
Serum amyloid P component (SAP) is a member of the pentraxins family that plays important roles in innate immunity in vertebrates. In fish, the biological function of SAP is essentially unknown. In this study, we examined the expression and function of a SAP homologue (CsSAP) from tongue sole Cynoglossus semilaevis. CsSAP shares 46%-58% overall sequence identities with known fish SAP and was upregulated in expression by bacterial and viral infection. Recombinant CsSAP (rCsSAP) exhibited differential binding capacities to a wide range of Gram-positive and Gram-negative bacteria and promoted uptake of the bound bacteria by host phagocytes. When introduced in vivo, rCsSAP enhanced host resistance not only to bacterial infection but also to viral infection. Consistently, antibody blockage of CsSAP significantly weakened the ability of tongue sole to clear invading bacteria. These results provide the first evidence that fish SAP contributes significantly to both antibacterial and antiviral immunities. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据