期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 58, 期 6, 页码 505-515出版社
WILEY
DOI: 10.1111/dgd.12292
关键词
microcirculation; microdevice; self-organization; tissue culture
资金
- CREST program of Japan Science and Technology Agency
Organ culture systems are used to elucidate the mechanisms of pattern formation in developmental biology. Various organ culture techniques have been used, but the lack of microcirculation in such cultures impedes the long-term maintenance of larger tissues. Recent advances in microfluidic devices now enable us to utilize self-organized perfusable capillary networks in organ cultures. In this review, we will overview past approaches to organ culture and current technical advances in microfluidic devices, and discuss possible applications of microfluidics towards the study of developmental biology.
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