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Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
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NATURE CHEMICAL BIOLOGY (2019)
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The RNA N6-methyladenosine modification landscape of human fetal tissues
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NATURE CELL BIOLOGY (2019)
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Deciphering the m6A Code via Antibody-Independent Quantitative Profiling
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Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome
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PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression
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MOLECULAR CELL (2019)
m6A enhances the phase separation potential of mRNA
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The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112
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N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication
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SCIENCE (2019)
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
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CELL REPORTS (2019)
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
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MOLECULAR CELL (2019)
Chemical inhibitors make their RNA epigenetic mark
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NATURE REVIEWS DRUG DISCOVERY (2019)
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
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NATURE COMMUNICATIONS (2019)
Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase
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The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
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N-6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
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NATURE CHEMICAL BIOLOGY (2019)
m6A modification controls the innate immune response to infection by targeting type I interferons
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NATURE IMMUNOLOGY (2019)
Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase
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SCIENCE (2019)
Double-slit photoelectron interference in strong-field ionization of the neon dimer
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NATURE COMMUNICATIONS (2019)
RADAR: differential analysis of MeRIP-seq data with a random effect model
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m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes
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NATURE METABOLISM (2019)
Dynamic m6A modification regulates local translation of mRNA in axons
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NUCLEIC ACIDS RESEARCH (2018)
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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CELL (2018)
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
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CELL STEM CELL (2018)
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
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GENES & DEVELOPMENT (2018)
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
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HEPATOLOGY (2018)
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
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MOLECULAR CELL (2018)
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal
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MOLECULAR CELL (2018)
Recognition of RNA N6- methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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NATURE CELL BIOLOGY (2018)
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
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NATURE NEUROSCIENCE (2018)
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
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NEURON (2018)
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function
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NUCLEIC ACIDS RESEARCH (2018)
Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5 '-3 ' exoribonuclease XRN1
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RNA (2018)
Structural absorption by barbule microstructures of super black bird of paradise feathers
Dakota E. McCoy et al.
NATURE COMMUNICATIONS (2018)
METTL3-mediated m6 A modification is required for cerebellar development
Chen-Xin Wang et al.
PLOS BIOLOGY (2018)
Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
Seth D. Kasowitz et al.
PLOS GENETICS (2018)
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Yanan Yue et al.
CELL DISCOVERY (2018)
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion
Zhenrui Li et al.
CELL RESEARCH (2018)
Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration
Hu Wang et al.
CELL RESEARCH (2018)
Targeted m(6)A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs
Simone Rauch et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor
Katelyn A. Doxtader et al.
MOLECULAR CELL (2018)
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development
Mateusz Mendel et al.
MOLECULAR CELL (2018)
Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
Jiangbo Wei et al.
MOLECULAR CELL (2018)
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
Alessandro Bertero et al.
NATURE (2018)
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis
Junho Choe et al.
NATURE (2018)
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
Jun Liu et al.
NATURE CELL BIOLOGY (2018)
Structural insights into the RNA methyltransferase domain of METTL16
Agnieszka Ruszkowska et al.
SCIENTIFIC REPORTS (2018)
A dynamic N-6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors
Fei Yan et al.
CELL RESEARCH (2018)
RNA m6A modification enzymes shape innate responses to DNA by regulating interferon β
Rosa M. Rubio et al.
GENES & DEVELOPMENT (2018)
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Hailing Shi et al.
NATURE (2018)
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
Miaomiao Li et al.
GENOME BIOLOGY (2018)
METTL14 Suppresses the Metastatic Potential of Hepatocellular Carcinoma by Modulating N6-Methyladenosine- Dependent Primary MicroRNA Processing
Jin-Zhao Ma et al.
HEPATOLOGY (2017)
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
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NATURE (2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
Shengdong Ke et al.
GENES & DEVELOPMENT (2017)
RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome
A. Emilia Arguello et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Regulation of m6 A Transcripts by the 3' → 5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
Magdalena Natalia Wojtas et al.
MOLECULAR CELL (2017)
The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence
Ivayla Ivanova et al.
MOLECULAR CELL (2017)
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
Hua-Bing Li et al.
NATURE (2017)
m6A modulates haematopoietic stem and progenitor cell specification
Chunxia Zhang et al.
NATURE (2017)
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
Isaia Barbieri et al.
NATURE (2017)
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
Ly P. Vu et al.
NATURE MEDICINE (2017)
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
Xueyin Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
Raghu R. Edupuganti et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
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NEW PHYTOLOGIST (2017)
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
Nian Liu et al.
NUCLEIC ACIDS RESEARCH (2017)
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma
Xiao Li et al.
ONCOTARGET (2017)
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
Qi Cui et al.
CELL REPORTS (2017)
YTHDC1 mediates nuclear export of N6 - methyladenosine methylated mRNAs
Ian A. Roundtree et al.
ELIFE (2017)
The RNA Modification N6-methyladenosine and Its Implications in Human Disease
Pedro J. Batista
GENOMICS PROTEOMICS & BIOINFORMATICS (2017)
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation
Ki-Jun Yoon et al.
CELL (2017)
The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus
Qingliang Zheng et al.
NATURE IMMUNOLOGY (2017)
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
Zhen Lin et al.
CELL RESEARCH (2017)
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Phillip J. Hsu et al.
CELL RESEARCH (2017)
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
Kathryn E. Pendleton et al.
CELL (2017)
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program
Sicong Zhang et al.
CANCER CELL (2017)
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
Boris Slobodin et al.
CELL (2017)
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Hailing Shi et al.
CELL RESEARCH (2017)
RNA Binding to CBP Stimulates Histone Acetylation and Transcription
Daniel A. Bose et al.
CELL (2017)
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase
Zejuan Li et al.
CANCER CELL (2017)
The interaction of PRC2 with RNA or chromatin is mutually antagonistic
Manuel Beltran et al.
GENOME RESEARCH (2016)
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Wen Xiao et al.
MOLECULAR CELL (2016)
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
Ping Wang et al.
MOLECULAR CELL (2016)
Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Xiang Wang et al.
NATURE (2016)
m6A RNA methylation promotes XIST-mediated transcriptional repression
Deepak P. Patil et al.
NATURE (2016)
m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome
Benoit Molinie et al.
NATURE METHODS (2016)
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
Junhong Choi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex
Hao Du et al.
NATURE COMMUNICATIONS (2016)
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
Junhong Choi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Structural insights into the molecular mechanism of the m6A writer complex
Pawel Sledz et al.
ELIFE (2016)
5′ UTR m6A Promotes Cap-Independent Translation
Kate D. Meyer et al.
CELL (2015)
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
Claudio R. Alarcon et al.
CELL (2015)
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Xiao Wang et al.
CELL (2015)
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
Shengdong Ke et al.
GENES & DEVELOPMENT (2015)
Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
Caroline Roost et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
N6-methyladenosine marks primary microRNAs for processing
Claudio R. Alarcon et al.
NATURE (2015)
Structural imprints in vivo decode RNA regulatory mechanisms
Robert C. Spitale et al.
NATURE (2015)
N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
Nian Liu et al.
NATURE (2015)
Transcription factor trapping by RNA in gene regulatory elements
Alla A. Sigova et al.
SCIENCE (2015)
m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
Shay Geula et al.
SCIENCE (2015)
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Xiao-Li Ping et al.
CELL RESEARCH (2014)
m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
Pedro J. Batista et al.
CELL STEM CELL (2014)
Nascent RNA interaction keeps PRC2 activity poised and in check
Syuzo Kaneko et al.
GENES & DEVELOPMENT (2014)
N6-methyladenosine-dependent regulation of messenger RNA stability
Xiao Wang et al.
NATURE (2014)
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
Yang Wang et al.
NATURE CELL BIOLOGY (2014)
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Jianzhao Liu et al.
NATURE CHEMICAL BIOLOGY (2014)
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
Schraga Schwartz et al.
CELL REPORTS (2014)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Guanqun Zheng et al.
MOLECULAR CELL (2013)
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Kate D. Meyer et al.
CELL (2012)
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dan Dominissini et al.
NATURE (2012)
RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast
Sudeep D. Agarwala et al.
PLOS GENETICS (2012)
Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects
Zsuzsanna Bodi et al.
FRONTIERS IN PLANT SCIENCE (2012)
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Guifang Jia et al.
NATURE CHEMICAL BIOLOGY (2011)
Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis
Cintia F. Hongay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Inactivation of the Fto gene protects from obesity
Julia Fischer et al.
NATURE (2009)
An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data
Daniel Ramskold et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor
Silin Zhong et al.
PLANT CELL (2008)
The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines
E Kierzek et al.
NUCLEIC ACIDS RESEARCH (2003)
Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m6 a methyltransferase
JM Bujnicki et al.
JOURNAL OF MOLECULAR EVOLUTION (2002)
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