期刊
DEVELOPMENT
卷 143, 期 11, 页码 1907-1913出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.126854
关键词
Fibroblast growth factor (FGF); Vascular endothelial growth factor (VEGF); Heparan sulfate proteoglycan (HSPG); Sulfotransferase; Neuron migration; Axon guidance
资金
- Wellcome Trust [092839/Z/10/Z, 089775/Z/09/Z]
- International Brain Research Organization fellowship
- Wellcome Trust [092839/Z/10/Z, 089775/Z/09/Z] Funding Source: Wellcome Trust
The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neuronal migration and axon development. We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST (also known as HS2ST1) is important to regulate the migration of facial branchiomotor (FBM) neurons in the hindbrain. We have also investigated how HS2ST interacts with other signals in the hindbrain and show that fibroblast growth factor (FGF) signalling regulates FBM neuron migration in an HS2ST-dependent manner.
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