期刊
DEVELOPMENT
卷 143, 期 24, 页码 4558-4570出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.112672
关键词
Forkhead; Fox; Foregut development; Language acquisition; Pioneer factors; Transcription factors
资金
- National Institutes of Health [DK-P01-049120]
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human disease and, as such, various animal models have been generated to study the function of these transcription factors in mechanistic detail. In many cases, the absence of even a single Fox transcription factor is lethal. In this Primer, we provide an overview of the Fox family, highlighting several key Fox transcription factor families that are important for mammalian development.
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