期刊
ELECTROPHORESIS
卷 42, 期 21-22, 页码 2238-2245出版社
WILEY
DOI: 10.1002/elps.202000280
关键词
Human biofluids; Particle focusing; Viscoelasticity
资金
- Research Program through the National Research Foundation of Korea (NRF) [NRF2013R1A1A1A05007406, NRF-2019R1F1A1060512]
- Ajou University research fund
This study found that under pressure-driven microflows, particles in human saliva and blood plasma are influenced by their viscoelastic properties, forming a focused stream. The degree of particle focusing varies among samples, indicating that the viscoelasticity of biofluids may be affected by their compositions.
Saliva and blood plasma are non-Newtonian viscoelastic fluids that play essential roles in the transport of particulate matters (e.g., food and blood cells). However, whether the viscoelasticity of such biofluids alters the dynamics of suspended particles is still unknown. In this study, we report that under pressure-driven microflows of both human saliva and blood plasma, spherical particles laterally migrate and form a focused stream along the channel centerline by their viscoelastic properties. We observed that the particle focusing varied among samples on the basis of sampling times/donors, thereby demonstrating that the viscoelasticity of the human biofluids can be affected by their compositions. We showed that the particle focusing, observed in bovine submaxillary mucin solutions, intensified with the increase in mucin concentration. We expect that the findings from this study will contribute to the understanding of the physiological roles of viscoelasticity of human biofluids.
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