The Electrochemiluminescent Immunosensors for Point-of-care Testing of Methamphetamine Using a Portable Meter

The crowd of methamphetamine (METH) abuse has obviously increased during past decades, their physical and mental health are seriously jeopardized. It compelled growing worry worldwide so that there is an anxious requirement to develop the accurate, sensitive, rapid, and convenient detection techniques to tackle the problem. In regard to this matter, we reported two sensors for METH with synergistical alliance of sensitive electrochemiluminescence (ECL) quantification and specifically immune recognition. These sensors are applicable for point-of-care testing when equipped a portable ECL meter with outstanding performance, makes the feasibility of on-spot analysis. The dual-way analysis of immunosensors can be carried on, both exhibit unprecedented sensitivity toward METH. Here, AuNPs functioned indium tin oxide (ITO) coated polyethylene terephthalate (PET) is used as the basal electrode, providing excellent ECL background and supporting the sensing matrix. The real sample identification demonstrated the practicability and accuracy which met the requirement of forensic judgement and clinical treatment. This work provides a viable methodology and technology for a rapid and reliable analysis of hard drug abuser's samples.

Automated summary

The prevalence of methamphetamine (METH) abuse has increased significantly in recent decades, prompting a need for more accurate, sensitive, rapid, and convenient detection techniques to address this issue. Two sensors have been developed for METH detection, utilizing a combination of sensitive electrochemiluminescence (ECL) quantification and specific immune recognition, which can be applied for on-site testing with unprecedented sensitivity.