Selective and Sensitive Determination of Paracetamol and Levodopa with Using Electropolymerized 3,5-diamino-1,2,4-triazole Film on Glassy Carbon Electrode

For determination of levodopa (L-DOPA) and paracetamol (PAR), selective, effective and sensitive electrochemical sensor based on 3,5-diamino-1,2,4-triazole (35DT) on glassy carbon (GC) electrode was reported. The DPV method was used to obtain the oxidation peak current of L-DOPA which increased linearly with its concentration at the range of 1-99 mu M and 99-480 mu M. The linear relationship between the concentration of PAR and its peak current was obtained in the range of 0.3-55 mu M and 55-475 mu M. The limit of detection values for PAR and L-DOPA were found to be 0.1 and 0.25 mu M, respectively. Satisfactory results were obtained in pharmaceutical samples.

Automated summary

A selective electrochemical sensor based on 3,5-diamino-1,2,4-triazole on glassy carbon electrode was developed for the determination of levodopa and paracetamol, showing linear relationships between peak current and concentration within specific ranges. Detection limits for both substances were found to be sensitive and satisfactory in pharmaceutical samples.