期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 208, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2020.111479
关键词
Persistent organic pollutants; Neurodevelopment; Bayley-III; Infants
资金
- National Science Foundation of China [81973062]
- National Key Research and Development Program of China [2017YFC1600500]
- Science and Technology Commission of Shanghai Municipality [09DZ2200900]
This study investigated the relationship between prenatal exposure to persistent organic pollutants (POPs) and neurodevelopment in 18-month-old toddlers in Shanghai, China. The study found that beta-HCH concentration in cord serum was negatively related to motor development scores at 18 months, while p,p'-DDE was positively associated with language development. However, prenatal HCB levels were not linked to any of the Bayley-III subscales at 18 months.
As common environmental pollutants, persistent organic pollutants (POPs) that are widely applied in industry and agriculture have adverse effects on neurodevelopment. However, evidence on the neurotoxicity of POPs in neural development of offspring is limited. This study explored the relationship between prenatal exposure to POPs and neurodevelopment of 18-month-old toddlers in a mother-child cohort in Shanghai, China. In this study, we determined exposure levels of 37 POPs in cord blood serum collected at the time of delivery. The detection rate of pollutants HCB, beta-HCH, and p,p' -DDE was higher than 60%, so these will be discussed in the following analysis. From birth to approximately 18 months, we followed up infants to longitudinally explore whether POPs influenced their language, motor, and cognitive development according to a Bayley-III assessment. Based on multivariable regression analyses, the beta-HCH concentration in cord serum was negatively related to motor development scores in children at 18 months by adjusting for the covariates, but there was no change in language and cognition. Further piecewise linear regression analysis showed that a cord serum beta-HCH concentration greater than 0.2 mu g/L had a significantly negative correlation with the motor development scores. p,p'-DDE was positively associated with language development at 18 months before and after adjusting for covariates. But prenatal HCB levels were not associated with any of the Bayley-III subscales at 18 months. We concluded that prenatal exposure to beta-HCH might have adverse effects on infants' motor development. The minimum harmful concentration of beta-HCH was estimated at 0.2 mu g/L in cord serum. The unexpected positive association between p, p' -DDT and language development could be due to live birth bias.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据