期刊
DEVELOPMENT
卷 143, 期 2, 页码 197-210出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.124883
关键词
Cardiac conduction system; Cardiac development; Gene regulation; Transcriptional network
资金
- ZonMW-TOP
- Rembrandt Institute of Cardiovascular Science
- Fondation Leducq
The cardiac conduction system (CCS) consists of distinctive components that initiate and conduct the electrical impulse required for the coordinated contraction of the cardiac chambers. CCS development involves complex regulatory networks that act in stage-, tissue- and dose-dependent manners, and recent findings indicate that the activity of these networks is sensitive to common genetic variants associated with cardiac arrhythmias. Here, we review how these findings have provided novel insights into the regulatory mechanisms and transcriptional networks underlying CCS formation and function.
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