期刊
DEVELOPMENT
卷 143, 期 15, 页码 2803-2817出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.136010
关键词
LGN; Gpsm2; Papillae; Oral epithelia; Tongue; Placode; Oriented cell divisions; Hair follicle
资金
- National Institutes of Health T90 Training Grant [NIH/NIDCR 5T90DE021986-05]
- NIH Loan Repayment Plan [NOT-OD-15-122]
- Sidney Kimmel Foundation for Cancer Research [SKF-15-065]
- IBM Junior Faculty Development Award
Oral epithelia protect against constant challenges by bacteria, viruses, toxins and injury while also contributing to the formation of ectodermal appendages such as teeth, salivary glands and lingual papillae. Despite increasing evidence that differentiation pathway genes are frequently mutated in oral cancers, comparatively little is known about the mechanisms that regulate normal oral epithelial development. Here, we characterize oral epithelial stratification and describe multiple distinct functions for the mitotic spindle orientation gene LGN (Gpsm2) in promoting differentiation and tissue patterning in the mouse oral cavity. Similar to its function in epidermis, apically localized LGN directs perpendicular divisions that promote stratification of the palatal, buccogingival and ventral tongue epithelia. Surprisingly, however, in dorsal tongue LGN is predominantly localized basally, circumferentially or bilaterally and promotes planar divisions. Loss of LGN disrupts the organization and morphogenesis of filiform papillae but appears to be dispensable for embryonic hair follicle development. Thus, LGN has crucial tissue-specific functions in patterning surface ectoderm and its appendages by controlling division orientation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据