Dried blood spots for anti-doping: Why just going volumetric may not be sufficient

The perspective discusses quantitative DBS analysis for anti-doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented.

Automated summary

This perspective discusses quantitative DBS analysis for anti-doping testing in an athletic population and argues that using only volumetric sampling may not be sufficient. It provides examples of HCT variations, discusses the whole blood to plasma ratio and HCT extraction bias, and presents options to correct for the HCT bias.