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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines
Karolina Wojtowicz et al.
BIOMEDICINE & PHARMACOTHERAPY (2015)
Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis
Eric T. Alexander et al.
CANCER BIOLOGY & THERAPY (2015)
FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition
Zhijiao Zhou et al.
CANCER LETTERS (2015)
FOXF2 suppresses the FOXC2-mediated epithelial mesenchymal transition and multidrug resistance of basal-like breast cancer
Jun Cai et al.
CANCER LETTERS (2015)
TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma
Naoki Oshimori et al.
CELL (2015)
Molecular Pathways: Targeting Tumor-Infiltrating Myeloid-Derived Suppressor Cells for Cancer Therapy
Diletta Di Mitri et al.
CLINICAL CANCER RESEARCH (2015)
SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
Thomas T. Vellinga et al.
CLINICAL CANCER RESEARCH (2015)
Molecular basis of resistance to proteasome inhibitors in hematological malignancies
Denise Niewerth et al.
DRUG RESISTANCE UPDATES (2015)
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
Simone Meidhof et al.
EMBO MOLECULAR MEDICINE (2015)
Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms
Douglas B. Johnson et al.
EUROPEAN JOURNAL OF CANCER (2015)
Diminution of miR-340-5p levels is responsible for increased expression of ABCB5 in melanoma cells under oxygen-deprived conditions
Michal Wozniak et al.
EXPERIMENTAL AND MOLECULAR PATHOLOGY (2015)
Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1 alpha
Hui Gao et al.
EXPERIMENTAL CELL RESEARCH (2015)
Lessons From Anti-Vascular Endothelial Growth Factor and Anti-Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma
Christine Lu-Emerson et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng et al.
NATURE (2015)
Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9
Ya-Ling Hsu et al.
ONCOLOGY REPORTS (2015)
Epithelial-mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation
Linna Li et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma
Tian Qin et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)
Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer
Yingqian Lv et al.
ONCOTARGETS AND THERAPY (2015)
Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway
Sheng-Chun Wang et al.
ONCOTARGET (2015)
Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
Maxime Thoreau et al.
ONCOTARGET (2015)
A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
Ruth Sanchez-Martinez et al.
ONCOTARGET (2015)
The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer
Mahiru Kawano et al.
SCIENTIFIC REPORTS (2015)
Prediction of Cancer Drug Resistance and implications for Personalized Medicine
Manfred Volm et al.
FRONTIERS IN ONCOLOGY (2015)
Caveolae and cancer: A new mechanical perspective
Christophe Lamaze et al.
BIOMEDICAL JOURNAL (2015)
Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells
Lingjie Bao et al.
MOLECULAR MEDICINE REPORTS (2015)
Bidirectional effect of CD200 on breast cancer development and metastasis, with ultimate outcome determined by tumor aggressiveness and a cancer-induced inflammatory response
N. Erin et al.
ONCOGENE (2015)
Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
L. Jiang et al.
ONCOGENE (2015)
FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells
Wen-Tai Chiu et al.
ONCOTARGET (2015)
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
Jie Yuan et al.
BREAST CANCER RESEARCH (2015)
Mitochondria as biosynthetic factories for cancer proliferation
Christopher S. Ahn et al.
CANCER & METABOLISM (2015)
Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner
Heyang Xu et al.
BMC CANCER (2014)
Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells
Kamolporn Amornsupak et al.
BMC CANCER (2014)
G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration
K. T. Morris et al.
BRITISH JOURNAL OF CANCER (2014)
SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma
S. H. Lee et al.
BRITISH JOURNAL OF CANCER (2014)
Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells
Yanrong Qian et al.
CANCER LETTERS (2014)
Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma
Qing-Min Fan et al.
CANCER LETTERS (2014)
Kruppel-like factor 8 contributes to hypoxia-induced MDR in gastric cancer cells
Hui Zhang et al.
CANCER SCIENCE (2014)
Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance
Paraskevi Mallini et al.
CANCER TREATMENT REVIEWS (2014)
Lung Cancer Stem Cells and Implications for Future Therapeutics
Jing Wang et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
Suganthi Chittaranjan et al.
CLINICAL CANCER RESEARCH (2014)
Cancer stem cells - important players in tumor therapy resistance
Selcuk Colak et al.
FEBS JOURNAL (2014)
CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer
Kevin M. Hart et al.
IMMUNOLOGY AND CELL BIOLOGY (2014)
Cancer stem cells and radioresistance
Kiera Rycaj et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2014)
Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
Chen Qu et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)
Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells
Sunbin Ling et al.
MOLECULAR MEDICINE REPORTS (2014)
Lenalidomide enhances the protective effect of a therapeutic vaccine and reverses immune suppression in mice bearing established lymphomas
I. Sakamaki et al.
LEUKEMIA (2014)
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Oscar R. Colegio et al.
NATURE (2014)
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
Roy S. Herbst et al.
NATURE (2014)
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CH K1
Peijing Zhang et al.
NATURE CELL BIOLOGY (2014)
PGC-lα mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Valerie S. LeBleu et al.
NATURE CELL BIOLOGY (2014)
Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma
G. V. Long et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Involvement of HIF-1α activation in the doxorubicin resistance of human osteosarcoma cells
Laura Roncuzzi et al.
ONCOLOGY REPORTS (2014)
Effect of oxygen on multidrug resistance in term human placenta
M. Javam et al.
PLACENTA (2014)
Signaling mechanisms of the epithelial-mesenchymal transition
David M. Gonzalez et al.
SCIENCE SIGNALING (2014)
Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
Ubaldo E. Martinez-Outschoorn et al.
SEMINARS IN CANCER BIOLOGY (2014)
Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
S. Raz et al.
CELL DEATH & DISEASE (2014)
T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy
Ignacio Melero et al.
CANCER DISCOVERY (2014)
Tumor Initiating Cells and Chemoresistance: Which Is the Best Strategy to Target Colon Cancer Stem Cells?
Emanuela Paldino et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
William W. Wheaton et al.
ELIFE (2014)
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Hua Yu et al.
NATURE REVIEWS CANCER (2014)
A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44
Irina S. Babina et al.
BREAST CANCER RESEARCH (2014)
Rationally designed nanovehicles to overcome cancer chemoresistance
Yoav D. Livney et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator
Philip Vlaicu et al.
BMC CANCER (2013)
Macrophage Regulation of Tumor Responses to Anticancer Therapies
Michele De Palma et al.
CANCER CELL (2013)
Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
Jonathan B. Mitchem et al.
CANCER RESEARCH (2013)
Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
Eveline M. Dijkgraaf et al.
CANCER RESEARCH (2013)
Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Sarah-Maria Fendt et al.
CANCER RESEARCH (2013)
A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells
Yan Zhang et al.
CELL RESEARCH (2013)
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
Florian A. Siebzehnrubl et al.
EMBO MOLECULAR MEDICINE (2013)
Breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in breast cancer cells
Patsy S. H. Soon et al.
ENDOCRINE-RELATED CANCER (2013)
A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: Results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO)
Gary Middleton et al.
EUROPEAN JOURNAL OF CANCER (2013)
Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation
Moshe Sade-Feldman et al.
IMMUNITY (2013)
Circulating interleukin-6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy
Chin Hao Chang et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors
Deborah A. Knight et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients
David Vasquez-Dunddel et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
Fiorenza Lotti et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Increased Myeloid-Derived Suppressor Cells in Gastric Cancer Correlate with Cancer Stage and Plasma S100A8/A9 Proinflammatory Proteins
Linda Wang et al.
JOURNAL OF IMMUNOLOGY (2013)
Antitumor Effect of Paclitaxel Is Mediated by Inhibition of Myeloid-Derived Suppressor Cells and Chronic Inflammation in the Spontaneous Melanoma Model
Alexandra Sevko et al.
JOURNAL OF IMMUNOLOGY (2013)
Multi-Drug-Resistant Cells Enriched From Chronic Myeloid Leukemia Cells by Doxorubicin Possess Tumor-Initiating-Cell Properties
Hong Xin et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2013)
Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells
David J. Panka et al.
MOLECULAR CANCER (2013)
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
Jeong Heo et al.
NATURE MEDICINE (2013)
Candidate Markers That Associate with Chemotherapy Resistance in Breast Cancer through the Study on Taxotere-Induced Damage to Tumor Microenvironment and Gene Expression Profiling of Carcinoma-Associated Fibroblasts (CAFs)
Guohua Rong et al.
PLOS ONE (2013)
The role of IL-6 in the radiation response of prostate cancer
Chun-Te Wu et al.
RADIATION ONCOLOGY (2013)
Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
Lisa M. Coussens et al.
SCIENCE (2013)
Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux
Jian-ri Li et al.
TOXICOLOGY LETTERS (2013)
Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression
M. D. Bullock et al.
CELL DEATH & DISEASE (2013)
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
X. Sui et al.
CELL DEATH & DISEASE (2013)
Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells
Jin Xie et al.
ONCOLOGY LETTERS (2013)
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
Younghun Jung et al.
NATURE COMMUNICATIONS (2013)
Regulatory networks defining EMT during cancer initiation and progression
Bram De Craene et al.
NATURE REVIEWS CANCER (2013)
History of myeloid-derived suppressor cells
James E. Talmadge et al.
NATURE REVIEWS CANCER (2013)
EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer
Alexandria M. Haslehurst et al.
BMC CANCER (2012)
HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemoresistance of invasive micropapillary carcinoma of the breast
Sophie Doublier et al.
BMC CANCER (2012)
Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology
Claudia A. Dumitru et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)
Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells
Yunfei Zhou et al.
CANCER RESEARCH (2012)
Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism
Su Yeon Lee et al.
CANCER RESEARCH (2012)
MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling
Sidong Huang et al.
CELL (2012)
A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
Swarnali Acharyya et al.
CELL (2012)
Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models
Massimo Zollo et al.
CLINICAL & EXPERIMENTAL METASTASIS (2012)
SIRT1, metabolism and cancer
John R. P. Knight et al.
CURRENT OPINION IN ONCOLOGY (2012)
Molecular Link Mechanisms between Inflammation and Cancer
D. B. Vendramini-Costa et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance
Nitzan Gonen et al.
DRUG RESISTANCE UPDATES (2012)
Regulation of Immune Responses by Prostaglandin E-2
Pawel Kalinski
JOURNAL OF IMMUNOLOGY (2012)
Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth
Eva Schlecker et al.
JOURNAL OF IMMUNOLOGY (2012)
Monocyte chemoattractant protein-1 mediates angiotensin II-induced vascular smooth muscle cell proliferation via SAPK/JNK and ERK1/2
Hua-Li Yao et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)
Interleukin-6: A multifunctional targetable cytokine in human prostate cancer
Zoran Culig et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth
Xi-Qiu Liu et al.
MOLECULAR PHARMACEUTICS (2012)
Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1
Chii-Wen Chou et al.
NEURO-ONCOLOGY (2012)
Sox2 expression in breast tumours and activation in breast cancer stem cells
O. Leis et al.
ONCOGENE (2012)
TGF-β autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression
Maria Cecilia Daroqui et al.
ONCOLOGY REPORTS (2012)
Short hairpin RNA targeting Twist1 suppresses cell proliferation and improves chemosensitivity to cisplatin in HeLa human cervical cancer cells
Kexiu Zhu et al.
ONCOLOGY REPORTS (2012)
Induction of epithelial-mesenchymal transition by transforming growth factor β
Aristidis Moustakas et al.
SEMINARS IN CANCER BIOLOGY (2012)
Melanoma-induced immunosuppression and its neutralization
Viktor Umansky et al.
SEMINARS IN CANCER BIOLOGY (2012)
Differential macrophage programming in the tumor microenvironment
Brian Ruffell et al.
TRENDS IN IMMUNOLOGY (2012)
Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells
G. M. A. Ajabnoor et al.
CELL DEATH & DISEASE (2012)
Multidrug resistance in breast cancer cells during epithelial-mesenchymal transition is modulated by breast cancer resistant protein
Wei-Juan Chen et al.
Chinese Journal of Cancer (2012)
Coordinated regulation of myeloid cells by tumours
Dmitry I. Gabrilovich et al.
NATURE REVIEWS IMMUNOLOGY (2012)
Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development
Wei-Liang Sun et al.
AUTOPHAGY (2011)
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
Natasa Obermajer et al.
BLOOD (2011)
Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation
Hyung Gyun Kim et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PIGF
Charlotte Rolny et al.
CANCER CELL (2011)
Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
Roberta Mazzieri et al.
CANCER CELL (2011)
COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells
Mitsugu Fujita et al.
CANCER RESEARCH (2011)
Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
Alina Shapira et al.
DRUG RESISTANCE UPDATES (2011)
Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma
S. John Weroha et al.
GYNECOLOGIC ONCOLOGY (2011)
Regulation of hypoxia inducible factor-1α expression by the alteration of redox status in HepG2 cells
Wen-sen Jin et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)
M2 Macrophages Induced by Prostaglandin E2 and IL-6 from Cervical Carcinoma Are Switched to Activated M1 Macrophages by CD4+ Th1 Cells
Moniek Heusinkveld et al.
JOURNAL OF IMMUNOLOGY (2011)
The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models
L. L. Swystun et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
p38 MAPK Controls Prothrombin Expression by Regulated RNA 3′ End Processing
Sven Danckwardt et al.
MOLECULAR CELL (2011)
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
Masahisa Jinushi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
Christiane Meyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
M. Donadelli et al.
CELL DEATH & DISEASE (2011)
Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
M. Saxena et al.
CELL DEATH & DISEASE (2011)
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
David G. DeNardo et al.
CANCER DISCOVERY (2011)
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian et al.
CELL (2010)
Immunity, Inflammation, and Cancer
Sergei I. Grivennikov et al.
CELL (2010)
The reverse Warburg effect Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
Gloria Bonuccelli et al.
CELL CYCLE (2010)
Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
Alejandro Vazquez-Martin et al.
CELL CYCLE (2010)
Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects
Wei Zhang et al.
CLINICAL CANCER RESEARCH (2010)
Inflammation and coagulation
Marcel Levi et al.
CRITICAL CARE MEDICINE (2010)
Transforming growth factor beta (TGF-β) and inflammation in cancer
Brian Bierie et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2010)
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
Zhenyu Ding et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)
Expression of MDR1, HIF-1α and MRP1 in sacral chordoma and chordoma cell line CM-319
Zhengang Ji et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)
Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
Ming Zhou et al.
MOLECULAR CANCER (2010)
Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells
S-H Lee et al.
ONCOGENE (2010)
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
A. Singh et al.
ONCOGENE (2010)
TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Zhan Yao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
Marcin Kowanetz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Macrophages as mediators of tumor immunosurveillance
Siddhartha Jaiswal et al.
TRENDS IN IMMUNOLOGY (2010)
An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers
Agnieszka K. Witkiewicz et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Inflammation and Cancer: IL-6 and STAT3 Complete the Link
Jacqueline Bromberg et al.
CANCER CELL (2009)
Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
Heather A. Hirsch et al.
CANCER RESEARCH (2009)
Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
Thiruvengadam Arumugam et al.
CANCER RESEARCH (2009)
The reverse Warburg effect Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides et al.
CELL CYCLE (2009)
Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2
L. Moro et al.
CELL DEATH AND DIFFERENTIATION (2009)
TGF-β-induced epithelial to mesenchymal transition
Jian Xu et al.
CELL RESEARCH (2009)
Tumor and Host-Mediated Pathways of Resistance and Disease Progression in Response to Antiangiogenic Therapy
John M. L. Ebos et al.
CLINICAL CANCER RESEARCH (2009)
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
Qing-Quan Li et al.
CLINICAL CANCER RESEARCH (2009)
Granulocyte colony-stimulating factor receptor: Stimulating granulopoiesis and much more
Clifford Liongue et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
Henry S. Friedman et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
FDA Drug Approval Summary: Bevacizumab (Avastin (R)) as Treatment of Recurrent Glioblastoma Multiforme
Martin H. Cohen et al.
ONCOLOGIST (2009)
Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G1 phase cell cycle arrest
Sayaka Yoshiba et al.
ORAL ONCOLOGY (2009)
Gene Expression Profiling of Adenosine Triphosphate-Binding Cassette Transporters in Response to K-ras Activation and Hypoxia in Human Pancreatic Cancer Cell Cultures
Maisie Lo et al.
PANCREAS (2009)
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
Farbod Shojaei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate
Allison S. Harney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
Nawneet K. Kurrey et al.
STEM CELLS (2009)
Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1α in human colon cancer cells
Chiara Riganti et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)
The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells
Stefania Meschini et al.
AUTOPHAGY (2008)
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation - Implications for the response to hormonal therapy
Isabelle Mercier et al.
CANCER BIOLOGY & THERAPY (2008)
Autocrine IL-6 signaling: A key event in tumorigenesis?
Sergei Grivennikov et al.
CANCER CELL (2008)
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
Li Yang et al.
CANCER CELL (2008)
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells
Pravin J. Mishra et al.
CANCER RESEARCH (2008)
Insulin-like growth factor-l-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
Tisheeka R. Graham et al.
CANCER RESEARCH (2008)
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
Olga Turovskaya et al.
CARCINOGENESIS (2008)
The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
Paola Allavena et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)
Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
Jing Yang et al.
DEVELOPMENTAL CELL (2008)
Re-educating tumor-associated macrophages by targeting NF-κB
Thorsten Hagemann et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells
Georg Varga et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
The role of myeloid cells in the promotion of tumour angiogenesis
Craig Murdoch et al.
NATURE REVIEWS CANCER (2008)
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
Farbod Shojaei et al.
NATURE (2007)
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
Kevin G. Leong et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Anti-PIGF inhibits growth of VEGF(R)-Inhibitor-Resistant tumors without affecting healthy vessels
Christian Fischer et al.
CELL (2007)
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
Hui-Wen Lo et al.
CANCER RESEARCH (2007)
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
Farbod Shojaei et al.
NATURE BIOTECHNOLOGY (2007)
CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers
Bo Huang et al.
CANCER LETTERS (2007)
Role of hypoxia-inducible factor-α in hepatitis-B-virus X protein-mediated MDR1 activation
Hyo-Kyung Han et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Granulocyte colony-stimulating factor/granulocyte colony-stimulating factor receptor biological axis promotes survival and growth of baldder cancer cells
Arup Chakraborty et al.
UROLOGY (2007)
Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
Pratima Sinha et al.
CANCER RESEARCH (2007)
Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver
Caroline Fradette et al.
DRUG METABOLISM AND DISPOSITION (2007)
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and snail
Hyun-Jung Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
George Z. Cheng et al.
CANCER RESEARCH (2007)
The involvement of hypoxia-inducible factor-1α in the susceptibility to γ-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells
Eri Sasabe et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
ABCG2: determining its relevance in clinical drug resistance
Robert W. Robey et al.
CANCER AND METASTASIS REVIEWS (2007)
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
Jong In Yook et al.
NATURE CELL BIOLOGY (2006)
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1α gene
Xianrang Song et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype
Mary Lynn Nierodzik et al.
CANCER CELL (2006)
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
Stefan Grotegut et al.
EMBO JOURNAL (2006)
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
Yehuda G. Assaraf
DRUG RESISTANCE UPDATES (2006)
Knockdown of hypoxia-inducible factor-1α in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate
J Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Adding chloroquine to conventional treatment for glioblastoma multiforme -: A randomized, double-blind, placebo-controlled trial
J Sotelo et al.
ANNALS OF INTERNAL MEDICINE (2006)
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
J Condeelis et al.
CELL (2006)
Snail induction is an early response to Gli1 that determines the effciency of epithelial transformation
X Li et al.
ONCOGENE (2006)
Persistent activation of Stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
T Gritsko et al.
CLINICAL CANCER RESEARCH (2006)
Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
SK Bunt et al.
JOURNAL OF IMMUNOLOGY (2006)
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
PC Rodriguez et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Transforming growth factor-β1 immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system
F Weber et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2005)
Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids
M Wartenberg et al.
FEBS LETTERS (2005)
Pharmacogenetics for individualized cancer chemotherapy
T Efferth et al.
PHARMACOLOGY & THERAPEUTICS (2005)
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells
TN Hartmann et al.
ONCOGENE (2005)
TGF-β1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells
M Ahmadzadeh et al.
JOURNAL OF IMMUNOLOGY (2005)
TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
JC Marie et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Human neuroblastoma cells exposed to hypoxia:: induction of genes associated with growth, survival, and aggressive behavior
A Jögi et al.
EXPERIMENTAL CELL RESEARCH (2004)
Timeline - The evolution of thalidomide and its IMiD derivatives as anticancer agents
JB Bartlett et al.
NATURE REVIEWS CANCER (2004)
Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress
M Kajita et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1α-dependent P-glycoprotein expression in hypoxia
KM Comerford et al.
CANCER RESEARCH (2004)
The chemokine system in diverse forms of macrophage activation and polarization
A Mantovani et al.
TRENDS IN IMMUNOLOGY (2004)
Cutting edge:: TGF-β signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+ CD25+ T cells
S Huber et al.
JOURNAL OF IMMUNOLOGY (2004)
Bidirectional relation between inflammation and coagulation
M Levi et al.
CIRCULATION (2004)
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
P Krishnamurthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
BHP Zhou et al.
NATURE CELL BIOLOGY (2004)
Expansion of myeloid immune suppressor Gr+CD11b+cells in tumor-bearing host directly promotes tumor angiogenesis
L Yang et al.
CANCER CELL (2004)
Snail blocks the cell cycle and confers resistance to cell death
S Vega et al.
GENES & DEVELOPMENT (2004)
Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines -: Mechanisms for epithelial mesenchymal transitions
H Peinado et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Reduction of Tc-99m-sestamibi and Tc-99m-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function
S Kinuya et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2003)
Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro
S Koch et al.
BRITISH JOURNAL OF CANCER (2003)
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxiainducible factor-1 and reactive oxygen species
M Wartenberg et al.
FASEB JOURNAL (2003)
G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells
T Natori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Multidrug resistance in cancer: Role of ATP-dependent transporters
MM Gottesman et al.
NATURE REVIEWS CANCER (2002)
Non-melanoma skin cancers and glucocorticoid therapy
MR Karagas et al.
BRITISH JOURNAL OF CANCER (2001)
Coexpression of granulocyte colony stimulating factor and its receptor in primary ovarian carcinomas
TM Savarese et al.
CANCER LETTERS (2001)
Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis
M Stolina et al.
JOURNAL OF IMMUNOLOGY (2000)
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