期刊
DRUG DISCOVERY TODAY
卷 26, 期 1, 页码 56-68出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2020.10.022
关键词
-
资金
- ANR project BIKET [ANR-17-CE17-0008]
- University Hospital Institute (IHU)-European Center for Transplantation and Immunotherapy Services (CESTI)
- LabEX IGO
- French Government [ANR-10-IBHU-005, ANR-11LABX-0016-01]
Tetraspanins are a well-conserved superfamily of small membrane proteins in humans with important roles in cell biology, including cellular development, proliferation, activation, motility, and membrane fusions. Due to their diverse physiological functions, tetraspanins are considered regulators of cellular signaling and may play important roles in pathological processes.
Tetraspanins constitute a well-conserved superfamily of four-span small membrane proteins (TM4SF), with >30 members in humans, with important roles in numerous mechanisms of cell biology. Moreover, tetraspanins associate with either specific partner proteins or another tetraspanin, generating a network of interactions involved in cell and membrane compartmentalization and having a role in cellular development, proliferation, activation, motility, and membrane fusions. Therefore, tetraspanins are considered regulators of cellular signaling and are often depicted as ?molecular facilitators?. In view of these many physiological functions, it is likely that these molecules are important actors in pathological processes. In this review, we present the main characteristics of this superfamily, providing a more detailed description of some significant representatives and discuss their relevance as potential targets for the design and development of small-molecule therapeutics in different
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据