Oral peptide delivery: challenges and the way ahead

Peptides and proteins have emerged as potential therapeutic agents and, in the search for the best treatment regimen, the oral route has been extensively evaluated because of its non-invasive and safe nature. The physicochemical properties of peptides and proteins along with the hurdles in the gastrointestinal tract (GIT), such as degrading enzymes and permeation barriers, are challenges to their delivery. To address these challenges, several conventional and novel approaches, such as nanocarriers, site-specific and stimuli specific delivery, are being used. In this review, we discuss the challenges to the oral delivery of peptides and the approaches used to tackle these challenges.

Automated summary

Oral delivery presents challenges in the delivery of peptides and proteins due to degrading enzymes and permeation barriers in the gastrointestinal tract. Researchers are exploring conventional and novel approaches, such as nanocarriers, to tackle these challenges in delivering therapeutic agents effectively.