期刊
DRUG AND CHEMICAL TOXICOLOGY
卷 45, 期 4, 页码 1660-1669出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01480545.2020.1853765
关键词
Nano-titanium nitride; Danio rerio; development; oxidative stress; Nrf2
资金
- International Science and Technology Cooperation project of Shandong Academy of Sciences [2019GHPY13]
- Science, Education and Industry Integration Innovation Pilot Project of Qilu University of Technology (Shandong Academy of Sciences) [2020KJC-ZD10]
- National Key R&D Program of China [2018YFC1707300]
- Mount Taishan Scholar Program [tspd20181211]
Nano-titanium nitride (Nano-TiN) has been widely used in medical devices and jewelry due to its wear resistance, corrosion resistance, and biocompatibility. However, there are limited studies on the safety of Nano-TiN. This study found that Nano-TiN exposure caused dose- and time-dependent developmental toxicity in zebrafish embryos, affecting organ development and leading to oxidative stress.
Nano-titanium nitride (Nano-TiN) has strong resistance to wear and corrosion, good biocompatibility, and an attractive metallic luster. Nano-TiN is widely used in medical devices, such as orthopedic implants, syringe needles, coronary stents, and long-term dental implants, and also in imitation gold jewelry. Despite its widespread use, there are few reports describing safety evaluations of Nano-TiN. Here, we exposed healthy zebrafish embryos to different concentrations of Nano-TiN solution for five days, starting at about four hours post fertilization, and found that Nano-TiN caused dose- and time-dependent developmental toxicity. With increasing Nano-TiN concentration and length of exposure, mortality, and deformities gradually increased; body length shortened and hatching rate and motility were significantly reduced. We also found that exposure to Nano-TiN affected development of the heart, liver, nerves, and other organs, and led to elevated levels of reactive oxygen species and reduced antioxidant capacity. Exposure to Nano-TiN resulted in downregulation of expression of antioxidant genes, such as nrf2, gclc, gclm, ho-1, and nqo1. Our results showed that exposure to Nano-TiN caused developmental and organ toxicity in zebrafish embryos and that the toxic effects may be mediated through oxidative stress.
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