4.7 Article

Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis

期刊

DEVELOPMENT
卷 143, 期 11, 页码 1948-1957

出版社

COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.131953

关键词

Fear-of-intimacy; ZIP transporters; Mesoderm development; Zinc-finger transcription factors; Drosophila

资金

  1. Ministerio de Economia y Competitividad [BFU2010-14884, BFU2013-45430-P]

向作者/读者索取更多资源

Zinc is a component of one-tenth of all human proteins. Its cellular concentration is tightly regulated because its dyshomeostasis has catastrophic health consequences. Two families of zinc transporters control zinc homeostasis in organisms, but there is little information about their specific developmental roles. We show that the ZIP transporter Fear-of-intimacy (Foi) is necessary for the formation of Drosophila muscles. In foi mutants, myoblasts segregate normally, but their specification is affected, leading to the formation of a misshapen muscle pattern and distorted midgut. The observed phenotypes could be ascribed to the inactivation of specific zincfinger transcription factors (ZFTFs), supporting the hypothesis that they are a consequence of intracellular depletion of zinc. Accordingly, foi phenotypes can be rescued by mesodermal expression of other ZIP members with similar subcellular localization. We propose that Foi acts mostly as a transporter to regulate zinc intracellular homeostasis, thereby impacting on the activity of ZFTFs that control specific developmental processes. Our results additionally suggest a possible explanation for the presence of large numbers of zinc transporters in organisms based on differences in ion transport specificity and/ or degrees of activity among transporters.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据