期刊
DISEASES OF AQUATIC ORGANISMS
卷 142, 期 -, 页码 177-187出版社
INTER-RESEARCH
DOI: 10.3354/dao03541
关键词
Amphibian disease; Histopathology; Liver degeneration; Melanomacrophage cells
资金
- Sao Paulo Research Foundation [FAPESP 2016/25358-3]
- National Council for Scientific and Technological Development [CNPq 300896/2016-6]
- Coordination for the Improvement of Higher Education Personnel (CAPES) [001, 1106071]
Amphibians have been facing a pandemic caused by the deadly fungus Batrachochytrium dendrobatidis (Bd). Although studies have elucidated cutaneous and homeostatic disturbances, it is still unknown if the hepatic function can be affected or if hepatic effects differ among host species. Thus, we evaluated the effects of an experimental Bd infection on the liver (histopathology and the hepatosomatic index) of 2 anuran species (Xenopus laevis and Physalaemus albonotatus) with different susceptibilities to Bd infection and compared them to uninfected controls. Bd infection increased the melanomacrophage cell area and induced leukocyte infiltration in both species. The effects were more pronounced in the sensitive species, P. albonotatus, which showed severe reduction in glycogen stores and liver atrophy, due to energetic imbalance. Hepatocytes of P. albonotatus also showed ballooning degeneration (vacuolization), which could lead to cell death and liver failure. Our results provide evidence that although the sensitive species showed more severe effects, the tolerant species also had hepatic responses to the infection. These findings indicate that hepatic function can play an important role in detoxification and in immune responses to chytridiomycosis, and that it may be used as a new biomarker of health status in chytrid infections.
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