期刊
DEVELOPMENT
卷 143, 期 11, 页码 1838-1847出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.128074
关键词
CircRNA; Splicing; Regulation; Development; Non-coding RNA
资金
- National Cancer Institute
- National Institute of General Medical Sciences
- McCormick-Gabilan Fellowship (Stanford University School of Medicine)
- Donald E. and Delia B. Baxter Foundation Faculty Scholars Award
- Lucille P. Markey Biomedical Research Fellowship
- National Science Foundation Graduate Research Fellowship Program
Just a few years ago, it had been assumed that the dominant RNA isoforms produced from eukaryotic genes were variants of messenger RNA, functioning as intermediates in gene expression. In early 2012, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree of life. These features suggest important functions for these molecules. Here, we describe major advances in the field of circRNA biology, focusing on the regulation of and functional roles played by these molecules.
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