期刊
DEVELOPMENT
卷 143, 期 7, 页码 1063-1074出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.128314
关键词
Cell heterogeneity; Lineage differentiation; Morphogenesis; Mouse; Preimplantation
资金
- Canadian Institutes of Health Research (CIHR) [MOP111197]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN 418720]
- Agence Nationale de la Recherche (ANR) PrEpiSpec
- French Cancer Research Association (ARC) [PJA20131200380]
During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In recent years, studies have shown that this process appears to be regulated by differences in cell-cell interactions, gene expression and the microenvironment of individual cells, rather than the active partitioning of maternal determinants. Precisely how these differences first emerge and how they dictate subsequent molecular and cellular behaviours are key questions in the field. As we review here, recent advances in live imaging, computational modelling and single-cell transcriptome analyses are providing new insights into these questions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据