期刊
DEVELOPMENT
卷 143, 期 1, 页码 3-14出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.130633
关键词
Age-related diseases; Hematopoietic stem cells; Multicellular organisms
资金
- National Institutes of Health
- Ovaxon, a fertility company
- Paul F. Glenn Foundation
- United Mitochondrial Disease Foundation
- Ovascience
- NATIONAL INSTITUTE ON AGING [R37AG028730] Funding Source: NIH RePORTER
All multicellular organisms undergo a decline in tissue and organ function as they age. An attractive theory is that a loss in stem cell number and/or activity over time causes this decline. In accordance with this theory, aging phenotypes have been described for stem cells of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and germline. Here, we discuss recent advances in our understanding of why adult stem cells age and how this aging impacts diseases and lifespan. With this increased understanding, it is feasible to design and test interventions that delay stem cell aging and improve both health and lifespan.
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