期刊
DIGESTIVE ENDOSCOPY
卷 33, 期 7, 页码 1146-1157出版社
WILEY
DOI: 10.1111/den.13912
关键词
adverse event; bleeding; needle tract seeding; pancreatitis
资金
- Japan Society for the Promotion of Science [18K07867]
- Grants-in-Aid for Scientific Research [18K07867] Funding Source: KAKEN
The study revealed that adverse events related to EUS-FNA for histopathologic diagnoses were uncommon, with low incidence rates of bleeding and pancreatitis being the main concerns. Bleeding was the most common adverse event, but in most cases, blood transfusion was not required.
Background and Aims: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is used for the histopathological diagnosis of any type of gastrointestinal disease. Few adverse events are experienced with this procedure; however, the actual rate of adverse events remains unclear. This study aimed to clarify the current status of cases that experienced adverse events related to the EUS-FNA procedure used for histopathologic diagnoses. Methods: A retrospective analysis of cases with EUS-FNA-related adverse events in Japanese tertiary centers was conducted by assessing the following clinical data: basic case information, FNA technique, type of procedural adverse events, and prognosis. Results: Of the 13,566 EUS-FNA cases overall, the total number of cases in which adverse events related to EUS-FNA occurred was 234. The incidence of EUS-FNA-related adverse events was similar to 1.7%. Bleeding and pancreatitis cases accounted for similar to 49.1% and 26.5% of all adverse events, respectively. Bleeding was the most common adverse event with only seven cases requiring blood transfusion. In cases with neuroendocrine tumors, pancreatitis was the most frequent adverse event. Needle tract seeding because of EUS-FNA was observed during the follow-up period in only similar to 0.1% of cases with pancreatic cancer. There was no mortality because of adverse events caused by EUS-FNA. Conclusions: This study revealed that the adverse events-related EUS-FNA for histopathologic diagnoses were not severe conditions, and had low incidence.
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