期刊
DIABETES-METABOLISM RESEARCH AND REVIEWS
卷 37, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/dmrr.3437
关键词
Chinese; chronic kidney disease; cohort study; metabolic syndrome; meta‐ analysis
资金
- International Postdoctoral Exchange Fellowship of the China Postdoctoral Council [20180062]
The study found a significant association between metabolic syndrome and incident chronic kidney disease in middle-aged and elderly Chinese population. A meta-analysis of cohort studies further supported this conclusion. It is recommended to regularly monitor renal functions in individuals with metabolic syndrome.
Aims We prospectively examined the relationship between metabolic syndrome (MetS) and incident chronic kidney disease (CKD) among middle-aged and elderly Chinese, and conducted a systematic review and meta-analysis of all cohort studies on this topic. Materials and Methods Our research data were derived from the China Health and Retirement Longitudinal Study. Participants (n=5752, age >= 45 years) without CKD (defined as estimated glomerular filtration rate <60 ml/min/1.73m(2)) at baseline were followed up for 4 years. We applied logistic regressions to examine the association of MetS with incident CKD. In addition, we pooled our effect estimates and those from previous cohort studies in the meta-analysis. Results In a 4-years follow-up, 61 (4.27%) developed CKD in participants with MetS versus 102 (2.36%) in participants without MetS. After adjustment for potential confounders, odds ratio for incident CKD was 1.82 [95% confidence interval (95% CI): 1.19-2.78] comparing participants with MetS with those without MetS. There was a linear positive association between the number of MetS components and incident CKD (p for trend <0.001). In the updated meta-analysis of 25 studies among 350,655 participants with 29,368 incident cases of CKD, the pooled relative risk of developing CKD in participants with MetS was 1.34 (95% CI: 1.28-1.39), compared with those without MetS. Conclusions Individuals with MetS had higher risk of incident CKD in middle-aged and elderly Chinese adults, which was supported by a comprehensive review of cohort studies from multiple populations. It may be advisable to routinely monitor renal functions among individuals with MetS.
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