期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 171, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2020.108623
关键词
Gestational diabetes mellitus; Twin pregnancies; Perinatal outcomes; Offspring growth profiles
资金
- National Key R&D Programof China [2018YFC1002900]
- National Natural Science Foundation of China [81520108013, 81771613, 81901508]
- Chongqing Science and Technology Commission [cstc2017jcyjBX0045]
- NHC Key Laboratory of Birth Defects and Reproductive Health [2018-5]
Gestational diabetes mellitus (GDM) has a greater impact on adverse perinatal outcomes and the risk of childhood overweight at 6 months for monochorionic diamniotic (MCDA) twin pregnancies compared to dichorionic diamniotic (DCDA) twin pregnancies. Twin offspring exposed to GDM had a higher risk of being overweight at 6 months of corrected age regardless of chorionicity.
Aims: To evaluate the influence of gestational diabetes mellitus (GDM) on the perinatal outcomes of twin pregnancies and its impact on fetal growth profiles of twin offspring from 6 weeks to 12 months of corrected age. Methods: A longitudinal cohort study was conducted among pregnant women with twins and their twin offspring. All information on perinatal outcomes and child growth trajectories from 6 weeks to 12 months of corrected age were obtained and analyzed using a general linear model and logistic regression models. Results: GDM was not correlated with adverse perinatal outcomes of twin pregnancies; however, in monochorionic diamniotic (MCDA), but not dichorionic diamniotic (DCDA) twin pregnancies, GDM was correlated with gestational hypertension disorder and a fetus being small for gestational age (OR, 2.68; 95% CI 1.16-6.04 and OR, 0.35; 95% CI 0.16-0.76, respectively). In both MCDA and DCDA groups, GDM was positively associated with a higher risk of childhood overweight at 6 months of corrected age (2.32 [1.05, 5.09] and 2.00 [1.13, 3.53]). Conclusions: GDM had a greater impact on MCDA twin pregnancies in terms of maternal gestational hypertension disease and small for gestational age of newborns. Additionally, twin offspring exposed to GDM had a higher risk of being overweight at 6 months of corrected age irrespective of chorionicity. (C) 2020 Elsevier B.V. All rights reserved.
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