Associations of changes in fat free mass with risk for type 2 diabetes: Hispanic Community Health Study/Study of Latinos

Aims: To determine whether loss of muscle mass (approximated using fat free mass [FFM]) is associated with risk for type 2 diabetes mellitus (T2DM) in Hispanic/Latino adults in the United States. Methods: Participants were Hispanic/Latino adults (18-74-year-olds) who completed Visit 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; multi-site, prospective cohort study; 6.1-year follow-up) and did not have T2DM at baseline (n = 6264). At baseline and Visit 2, FFM was measured using bioelectrical impedance analysis and fasting glucose, HbA1c, and fasting insulin were measured by examiners. Diabetes was defined according to American Diabetes Association criteria. Survey-weighted Poisson regression models examined the association of percent change in relative FFM (%AFFM) with incident prediabetes and T2DM. Survey-weighted multivariable regression models examined associations of %Delta FFM with changes in glucose and insulin measures. Results: Relative FFM declined by 2.1% between visits. %Delta FFM was inversely associated with incident prediabetes (p-for-trend = 0.001) and with changes in glucose and insulin measures (p-for-trend <0.0001). Findings were null, except for HOMA-IR, after adjustment for changes in adiposity measures. Associations were generally stronger for individuals with baseline overweight/obesity. Conclusions: Reducing loss of FFM during adulthood may reduce prediabetes risk (primarily insulin resistance), particularly among individuals with overweight/obesity. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

The study found that loss of muscle mass is associated with risk for type 2 diabetes mellitus in Hispanic/Latino adults in the United States, particularly among individuals with overweight/obesity. Reduction of muscle mass loss may reduce prediabetes risk, primarily insulin resistance.