期刊
DIABETES
卷 70, 期 1, 页码 29-38出版社
AMER DIABETES ASSOC
DOI: 10.2337/dbi19-0037
关键词
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资金
- Medical Research Council [MRC.MC.UU.12012.1]
- Wellcome Trust [208363/Z/17/Z, 214274/Z/118/Z]
- National Institute for Health Research
- MRC [MC_UU_00014/5, MC_UU_12012/1] Funding Source: UKRI
The study of human genetic mutations has significantly contributed to biomedical science, particularly in understanding insulin sensitivity and energy balance regulation. These studies have helped illuminate disturbances in insulin resistance and obesity in human metabolism.
The study of humans with genetic mutations which lead to a substantial disturbance of physiological processes has made a contribution to biomedical science that is disproportionate to the rarity of affected individuals. In this lecture, I discuss examples of where such studies have helped to illuminate two areas of human metabolism. First, the control of insulin sensitivity and its disruption in states of insulin resistance and second, the regulation of energy balance and its disturbances in obesity.
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