期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 63, 期 5, 页码 851-863出版社
WILEY
DOI: 10.1002/dev.22061
关键词
adolescent; early adversity; early experience; immune system; microbiome
资金
- Special BD LSR Fortessa Shared Instrumentation Grant [1S100OD018202-01]
- University of Wisconsin Carbone Cancer Center Support [P30 CA014520]
- National Science Foundation [00039202]
- Ontario Brain Institute
- Canadian Institute of Health Research
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R21 HD086312]
- PEO Scholar Award
- University of Minnesota Doctoral Dissertation Award
Early adverse care has long-term impacts on physical and mental health, and there may be a link between gut microbiota and immune alterations.
Early adverse care has long-term impacts on physical and mental health. The influence of rearing conditions on the infant's gut microbiota and its relationship with developmental health has become more evident. The microbiome is essential for normal growth and metabolism, and the signaling from the gut to the brain may underlie individual differences in resilience later in life. Microbial diversity and composition were determined using 16S rRNA gene amplicon sequencing in fecal samples from 17 adolescents adopted internationally from orphanages into the United States and 18 adolescents reared in birth families who had similar educational and income levels. Analyses focused on diversity of the microbial community structure and differences in the abundance of specific bacterial taxa. Blood samples were used to immunophenotype the numbers of several T-cell subsets and cytomegalovirus (CMV) seropositivity. Negative binomial regression analysis revealed several operational taxonomic units that were significantly different based on early rearing conditions and CMV seropositivity. There were significant associations between the relative abundance of certain taxa, the percentages of T-cell subsets in circulation, and CMV seropositivity. These findings demonstrate a possible link between the gut microbiota and associations with immune alterations initiated by early life adversity.
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