4.4 Review

Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives

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Article Dermatology

Low- dose systemic steroids, an emerging therapeutic option for COVID-19 related urticaria

Mohammed Shanshal

Summary: Dermatologists are reporting more skin manifestations of COVID-19 infection, with urticaria being a common reaction. The cytokine storm caused by the virus can lead to mast cell activation and urticaria. Low-dose systemic steroids and antihistamines can help control severe urticarial attacks related to COVID-19.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

Article Dermatology

Herpes zoster (shingles) complicating the course of COVID19 infection

Mohamed L. Elsaie et al.

Summary: Different skin presentations and patterns of cutaneous signs are observed in COVID-19 patients, including herpes zoster (HZ) as a common complication. Cutaneous skin findings have emerged as markers or complications of COVID-19.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

Review Allergy

SARS-CoV-2, COVID-19, skin and immunology - What do we know so far?

Natalijia Novak et al.

Summary: COVID-19 caused by SARS-CoV-2 can lead to respiratory symptoms as well as skin lesions and vascular system abnormalities in some patients. Understanding and identifying these skin manifestations and vascular changes are crucial for diagnosis and treatment of COVID-19 patients.

ALLERGY (2021)

Article Dermatology

The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series

C. M. Magro et al.

Summary: COVID-19-related perniosis represents an exaggerated immune reaction triggered by the virus with significant type I interferon signaling, which is crucial for SARS-CoV-2 eradication and may lead to a more generalized highly inflammatory response. In the thrombotic retiform purpura of critically ill patients with COVID-19, vascular thrombosis in the skin and other organ systems is associated with a minimal interferon response, allowing excessive viral replication and release of viral proteins that trigger extensive complement activation in extrapulmonary endothelium.

BRITISH JOURNAL OF DERMATOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Hyperacute multi-organ thromboembolic storm in COVID-19: a case report

Sarah Chibane et al.

Summary: This case report highlights a 66-year-old female COVID-19 patient who presented with multi-organ involvement, including livedo racemosa, acute renal failure, and myocardial injury, without respiratory symptoms. Echocardiography showed potential pulmonary microvascular thrombosis or embolism leading to right-sided cardiac overload. Despite therapeutic anticoagulation, the patient developed an acute ischemic stroke and died within 2 days of presentation. The predominantly thromboembolic presentation supports the concept of COVID-19 endotheliitis and the hyperacute multi-organ thromboembolic storm associated with the virus.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Article Pediatrics

Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease

Aman Gupta et al.

Summary: There have been reports of severe multi-system hyperinflammatory syndrome resembling Kawasaki disease in children during the current COVID-19 pandemic. Early recognition and treatment are crucial for these patients who have characteristic laboratory parameters and may benefit from immunomodulatory therapy.

JOURNAL OF TROPICAL PEDIATRICS (2021)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Letter Dermatology

Erythema multiforme-like eruption in patients with COVID-19 infection: clinical and histological findings

J. Jimenez-Cauhe et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2020)

Letter Dermatology

Cutaneous manifestations in COVID-19: familial cluster of urticarial rash

R. Cepeda-Valdes et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2020)

Review Dermatology

Contributions of dermatologists toCOVID-19 research: A brief systematic review

Yuanzhuo Wang et al.

DERMATOLOGIC THERAPY (2020)

Article Allergy

Complement activation in patients with COVID-19: A novel therapeutic target

Massimo Cugno et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Editorial Material Dermatology

A dermatologic manifestation of COVID-19: Transient livedo reticularis

Iviensan F. Manalo et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

Reply to COVID-19 can present with a rash and be mistaken for dengue: Petechial rash in a patient with COVID-19 infection

Juan Jimenez-Cauhe et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

Characterization of acute acral skin lesions in nonhospitalized patients: A case series of 132 patients during the COVID-19 outbreak

Diego Fernandez-Nieto et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

Varicella-like exanthem as a specific COVID-19-associated skin manifestation: Multicenter case series of 22 patients

Angelo Valerio Marzano et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

Chilblains is a common cutaneous finding during the COVID-19 pandemic: A retrospective nationwide study from France

Adele de Masson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

Cutaneous manifestations related to coronavirus disease 2019 (COVID-19): A prospective study from China and Italy

Vincenzo De Giorgi et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

COVID-19 can present with a rash and be mistaken for dengue

Beuy Joob et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Article Dermatology

Pernio-like skin lesions associated with COVID-19: A case series of 318 patients from 8 countries

Esther E. Freeman et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Letter Dermatology

Pityriasis rosea as a cutaneous manifestation of COVID-19 infection

A. H. Ehsani et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Urticaria-like lesions in COVID-19 patients are not really urticaria - a case with clinicopathological correlation

P. Rodriguez-Jimenez et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Histologic features of long-lasting chilblain-like lesions in a paediatric COVID-19 patient

A. G. Locatelli et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients

V. Piccolo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Are chilblain-like acral skin lesions really indicative of COVID-19? A prospective study and literature review

A. Docampo-Simon et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Cutaneous manifestations in COVID-19: the experiences of Barcelona and Rome

A. Tammaro et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

A clinicopathological study of eight patients with COVID-19 pneumonia and a late-onset exanthema

M. Herrero-Moyano et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Vascular skin symptoms in COVID-19: a French observational study

J. D. Bouaziz et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Cutaneous manifestations in COVID-19: a first perspective

S. Recalcati

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

SARS-CoV-2 infection presenting as a febrile rash

F. Amatore et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Article Dermatology

Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue?

Giovanni Genovese et al.

PEDIATRIC DERMATOLOGY (2020)

Article Dermatology

Cutaneous manifestations in hospitalized patients diagnosed asCOVID-19

Ozge Askin et al.

DERMATOLOGIC THERAPY (2020)

Letter Dermatology

A unilateral purpuric rash in a patient withCOVID-19 infection

Zeynep Karaca et al.

DERMATOLOGIC THERAPY (2020)

Article Dermatology

Maculopapular eruptions associated toCOVID-19: A subanalysis of theCOVID-Pielstudy

Alba Catala et al.

DERMATOLOGIC THERAPY (2020)

Letter Dermatology

Auricle perniosis as a manifestation of Covid-19 infection

Ilaria Proietti et al.

DERMATOLOGIC THERAPY (2020)

Review Dermatology

Cutaneous manifestations and considerations inCOVID-19 pandemic: A systematic review

Farnoosh Seirafianpour et al.

DERMATOLOGIC THERAPY (2020)

Review Dermatology

Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue

A. V. Marzano et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

Article Dermatology

Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic

Anne Herman et al.

JAMA DERMATOLOGY (2020)

Letter Dermatology

Clinicopathologic Aspects of a Papulovesicular Eruption in a Patient With COVID-19

Laurence Toutous Trellu et al.

JAMA DERMATOLOGY (2020)

Letter Dermatology

Acral purpuric lesions associated with coagulation disorders during the COVID-19 pandemic

Miguel Fernando Garcia-Gil et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2020)

Review Dermatology

Approach to Chilblains During the COVID-19 Pandemic

Malika A. Ladha et al.

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2020)

Letter Dermatology

Outbreak of chilblain-like acral lesions in children in the metropolitan area of Milan, Italy, during the COVID-19 pandemic

Cristiana Colonna et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Review Dermatology

Cutaneous manifestations of SARS-CoV-2 infection: a clinical update

P. Gisondi et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Cutaneous manifestations in SARS-CoV-2 infection (COVID-19): a French experience and a systematic review of the literature

S. Matar et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

A generalized purpuric eruption with histopathologic features of leucocytoclastic vasculitis in a patient severely ill with COVID-19

V. Caputo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Retiform purpura as a dermatological sign of coronavirus disease 2019 (COVID-19) coagulopathy

X. Bosch-Amate et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Histology of skin lesions establishes that the vesicular rash associated with COVID-19 is not 'varicella-like'

A. Mahe et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

An unusual case of bullous haemorrhagic vasculitis in a COVID-19 patient

S. Negrini et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

COVID-19 and outbreak of chilblains: are they related?

C. Lesort et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Papular-purpuric exanthem in a COVID-19 patient: clinical and dermoscopic description

J. Larrondo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Urticaria (angioedema) and COVID-19 infection

M. Najafzadeh et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Review Dermatology

COVID-19 and cutaneous manifestations: a systematic review

Qing Zhao et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Relapsing symmetric livedo reticularis in a patient with COVID-19 infection

M. Verheyden et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Dermoscopy features of COVID-19-related chilblains in children and adolescents

L. Navarro et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Catastrophic acute bilateral lower limbs necrosis associated with COVID-19 as a likely consequence of both vasculitis and coagulopathy

P. Del Giudice et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Drug reaction with eosinophilia and systemic symptoms syndrome in a patient with COVID-19

A. Herman et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Dermatology

Urticarial vasculitis in COVID-19 infection: a vasculopathy-related symptom?

D. de Perosanz-Lobo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Review Allergy

Association between urticaria and virus infections: A systematic review

Egidio Imbalzano et al.

ALLERGY AND ASTHMA PROCEEDINGS (2016)