期刊
CYTOMETRY PART A
卷 99, 期 3, 页码 231-242出版社
WILEY
DOI: 10.1002/cyto.a.24269
关键词
dendritic cells; monocytes; professional antigen‐ presenting cells; mononuclear phagocyte system; high‐ dimensional flow cytometry; phenotyping; human immunology
资金
- Intramural research program of the Vaccine Research Center, NIAID, NIH
- American Association of Immunologists
Professional antigen-presenting cells (APCs), including dendritic cells (DCs) and monocytes, play vital roles in inducing and guiding adaptive T-cell responses. Recent advancements in single-cell analysis have improved our understanding of APC subset heterogeneity, with novel phenotyping markers helping to accurately resolve functional diversity. This report provides a concise overview of traditional and recently described markers for characterizing DCs and monocytes in the human system.
Professional antigen-presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T-cell responses. Recent technological developments in single-cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue-specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine-grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report, we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system.
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