期刊
CYTOKINE
卷 147, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2020.155309
关键词
Leishmania; Wound healing macrophages; Supressive macrophages; Inflammatory macrophages; Monocytes; Monocyte-derived macrophages; M1; M2; Leishmaniasis
资金
- University of Calgary Snyder Institute Beverley Phillips Rising Star Fellowship
- Cumming School of Medicine Post-Doctoral Fellowship
- Coordenacao de Aperfeicoa-mento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
- CNPq [304588/2013-0]
- FAPEMIG - Brasil [RED-00313-16]
This article discusses the role and mechanisms of macrophages in Leishmania parasite infection, as well as the impact of vector bites on macrophage activation. Additionally, it explores the ontogeny of infected macrophages.
Macrophages are host cells for parasites of the genus Leishmania where they multiply inside parasitophorous vacuoles. Paradoxically, macrophages are also the cells responsible for killing or controlling parasite growth, if appropriately activated. In this review, we will cover the patterns of macrophage activation and the mechanisms used by the parasite to circumvent being killed. We will highlight the impacts of the vector bite on macrophage activation. Finally, we will discuss the ontogeny of macrophages that are infected by Leishmania spp.
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