Update on First-Line Combination Treatment Approaches in Metastatic Clear-Cell Renal Cell Carcinoma

Opinion statementThe treatment for metastatic renal cell carcinoma (mRCC) has significantly evolved in recent years with a deeper understanding of the molecular make-up of the disease and the clinical development of therapies with novel mechanisms of action. While some patients with more indolent disease may benefit from local therapy such as metastasectomy or cytoreductive nephrectomy, others may safely embark on an active surveillance program or be offered targeted therapy. Yet, a combination regimen including an ICI is the most effective regimen and should be considered in most mRCC cases. Ongoing studies will help determine which factors can be further used to optimize treatment selection and personalize disease management.

Automated summary

The treatment for metastatic renal cell carcinoma has evolved significantly in recent years, with options including local therapy, active surveillance, and targeted therapy. Combination regimens with ICI are the most effective and ongoing studies aim to optimize treatment selection for personalized disease management.