期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 22, 期 11, 页码 1444-1465出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201021666201211103856
关键词
Passive targeting; active targeting; EPR effect; TME remodeling; personalized nanomedicine; companion diagnostics
Nanomedicine is revolutionizing cancer treatment with unprecedented outcomes, but the heterogeneous nature of the EPR effect poses challenges. Active targeting strategies have shown limited success in enhancing therapeutic outcomes, prompting exploration of TME reengineering and the use of companion diagnostics to improve NP interactions with biological macromolecules.
Nanomedicine is revolutionizing the treatment of cancer and has achieved unprecedented outcomes over the past decades. The accumulation of Nanoparticles (NPs) in different tumors relies mainly on the Enhanced Permeability and Retention (EPR) effect benefiting from the wide fenestrae of the tumor vasculature and the lack of lymphatic drainage. However, the EPR effect is recognized as a heterogeneous phenomenon resulting in heterogeneous outcomes of clinical trials. Extensive efforts are exerted to enhance the outcomes of nanomedicine in a larger cohort of patients by employing active targeting strategies. However, actively targeted NPs accumulate in tumors by the EPR effect and hence fail to achieve convincing therapeutic outcomes. These obstacles are gradually being removed by improving the understanding of the Tumor Microenvironment (TME) and the mechanistic interaction of the NPs with its different components. In this review, we provide detailed insights into the past concerns of drug targeting, the current trends of TME reengineering, and the future implications for overcoming past hurdles. Strategies explored in this regard included the use of companion diagnostics and the modulation of the protein corona associated with the systemic administration of NPs and their interaction with biological macromolecules.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据