期刊
CURRENT ORGANIC SYNTHESIS
卷 19, 期 1, 页码 2-9出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570179418666210114145914
关键词
Pemetrexed disodium; pemetrexed glutamide impurity; multi-targeted antifolate; N-methyl pemetrexed glutamide; L-Glutamic acid; alimta
资金
- MSN Laboratories
A facile synthetic protocol was used to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The study describes the development of novel synthetic methods and their structure elucidation for Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. These impurities were deduced through spectral analysis and can serve as reference substances for quality control.
A facile synthetic protocol was employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis, such as H-1-NMR, (CNMR)-C-13, and HRMS. The target compounds can be used as the reference substances for quality control.
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