A Review on Thiocyanation of Indoles

Background: The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access 3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives. Objective: The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on its scope and mechanism. Conclusion: In this review, we have summarized various methods for the thiocyanation of indoles. Selection of new methods for the preparation of 3-thiocyanato-indoles will be done. The mechanistic aspects and significance of the methods are also briefly discussed.

Automated summary

This review highlights various methods for the thiocyanation of indoles and emphasizes the importance of studying new approaches for the preparation of 3-thiocyanato-indoles. The mechanistic aspects and significance of these methods are also briefly discussed.