期刊
CURRENT OPINION IN CELL BIOLOGY
卷 67, 期 -, 页码 37-45出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.07.004
关键词
Coordinated behaviour; Development; Biological scales; Feedback; Single cells; Self-organisation
类别
资金
- ERC under the European Union [758617]
- Swiss National Foundation [POOP3_157531]
- European Research Council (ERC) [758617] Funding Source: European Research Council (ERC)
Cells act as building blocks of multicellular organisms, forming higher-order structures at different biological scales. Niches, tissues and, ultimately, entire organisms consist of single cells that remain in constant communication. Emergence of developmental patterns and tissue architecture thus relies on single cells acting as a collective, coordinating growth, migration, cell fate transitions and cell type sorting. For this, information has to be transmitted forward from cells to tissues and fed back to the individual cell to allow dynamic and robust coordination. Here, we define the design principles of tissue organisation integrating chemical, genetic and mechanical cues. We also review the state-of-the-art technologies used for dissecting collective cellular behaviours at single cell- and tissue-level resolution. We finally outline future challenges that lie in a comprehensive understanding of how single cells coordinate across biological scales to insure robust development, homoeostasis and regeneration of tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据