期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 66, 期 -, 页码 95-104出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2020.06.012
关键词
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资金
- U.S. Department of Energy [DE-SC0018420, DE-SC0018260]
- U.S. Department of Energy (DOE) [DE-SC0018260] Funding Source: U.S. Department of Energy (DOE)
Microorganisms have been increasingly explored as microbial cell factories for production of fuels, chemicals, drugs, and materials. Among the various metabolic engineering strategies, directed genome evolution has emerged as one of the most powerful tools to unlock the full biosynthetic potential of microorganisms. Here we summarize the directed genome evolution strategies that have been developed in recent years, including adaptive laboratory evolution and various targeted genome-scale engineering strategies, and discuss their applications in basic and applied biological research.
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