期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 66, 期 -, 页码 186-194出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2020.08.002
关键词
-
资金
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [757384]
- Novo Nordisk Foundation [NNF10CC1016517]
Engineering the transport of small molecules is an effective approach to improve the performance of microbial cell factories. Transporter engineering can improve the utilization of low-cost alternative substrates, reduce the loss of pathway intermediates, and increase the titer and production rate of the target product. However, transporters are not commonly engineered in strain development programs because the functions of most of the transport proteins are not known. In the recent years, a variety of methods have been developed for identification of transporters for specific substrates and for characterizing transport mechanisms. This review presents recent examples of successful transport engineering for cell factories and discusses the methods for transporter identification and characterization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据