期刊
CURRENT GENETICS
卷 67, 期 3, 页码 369-382出版社
SPRINGER
DOI: 10.1007/s00294-020-01147-y
关键词
DNA replication checkpoint; RecQ; Helicase; Sgs1; Rqh1; WRN; BLM; RECQ1; RECQ4; RECQ5; Replication stress; Genomic instability; ATR; Rad3; Mec1; CHK1; Cds1; SOS response; Fission yeast; Budding yeast
资金
- NIH [GM110132]
The DNA replication checkpoint is activated in response to perturbed replication, with RecQ helicases playing various roles in this process. These helicases are conserved from bacteria to yeasts and humans, suggesting their importance in maintaining genomic integrity and cell survival.
DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large family of helicases that are conserved from bacteria to yeasts and humans, contribute to the replication checkpoint as sensors, adaptors, or regulation targets. Here, we highlight the multiple functions of RecQ helicases in the replication checkpoint in four model organisms and present additional evidence that fission yeast RecQ helicase Rqh1 may participate in the replication checkpoint as a sensor.
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