A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals

The solid dosage form is most preferred for the oral administration of drugs [1]. The modified oral drug delivery system is categorized into single-unit and multiple-unit dosage forms [2]. A single dose of multiple-unit dosage forms differs from that of single-unit dosage forms in terms of the size and number of units [3, 4]. Pellets, granules, microparticles, and mini tablets come under multiple-unit Oral route of administration is widely accepted and desired because of its versatility, convenience, and, most importantly, patient compliance. Multiparticulate systems like granules and pellets are more advantageous when compared to single-unit dosage forms, as they are capable of distributing the drug more evenly in the gastrointestinal tract. The current paper focuses on pellets, the merits and demerits associated, various pelletization techniques, and their characterization. It also focuses on how pellets can be employed for drug delivery is controlled and sustained release formulations. It gives a complete emphasis on the drug and excipients that can be used in pellet formation, the marketed formulations, and the research pertaining to pellets.

Automated summary

Oral administration using solid dosage forms, particularly multiple-unit dosage forms, is preferred due to its ability to evenly distribute the drug in the gastrointestinal tract.