A review on differential effects of dietary fatty acids on weight, appetite and energy expenditure

The association between weight and chronic diseases is well defined. The quality and quantity of dietary fatty acids is an important external factor and appetite and energy expenditure, are important internal factors in determining body weight. On the other hand, dietary fatty acids composition can modulate appetite and energy metabolism, but not all fats are equal in producing metabolic responses. Given the accumulating evidence for differential effects of various dietary fatty acids, one important area of investigation is to scrutinize their roles in weight, appetite and energy expenditure modulation. There is substantial evidence to suggest that saturated fatty acids have a greater effect on appetite control, although in the long run may result in more weight gain than unsaturated fatty acids due to a weaker stimulation of energy expenditure. In contrast, mono-unsaturated fats do not have much effects on appetite control, but they can be beneficial in weight control over the long term due to stimulatory effects on energy expenditure. Interestingly, in case of poly unsaturated fats, including n-3 and n-6, their effect on increasing energy expenditure is aligned, but they act differently in controlling weight and appetite.

Automated summary

The quality and quantity of dietary fatty acids play a significant role in weight, appetite, and energy expenditure. Saturated fatty acids have a greater impact on appetite control, while mono-unsaturated fats have stimulatory effects on energy expenditure and can be beneficial in long-term weight control. Poly unsaturated fats, including n-3 and n-6, have similar effects on increasing energy expenditure but act differently in controlling weight and appetite.