期刊
COORDINATION CHEMISTRY REVIEWS
卷 427, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2020.213577
关键词
Lipid droplets (LDs); Fluorescent probes; Intramolecular charge transfer (ICT); Aggregation-induced emission (AIE); Cellular imaging
资金
- NSFC [21788102, 91853201]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- National Key Sci-Tech Special Projects of Infection Diseases of China [2018ZX10732202]
- International Cooperation Program of Shanghai Science and Technology Committee [17520750100]
- Robert A. Welch Foundation [F-0018]
- Royal Society
Lipid droplets (LDs) are essential organelles for lipid and energy homeostasis. Despite progress in understanding LDs, there are still many fundamental questions unanswered. Effective imaging agents can help bridge the knowledge gap and facilitate the development of new therapeutics.
Lipid droplets (LDs) are cellular organelles that are essential for maintaining lipid and energy homeostasis. Once regarded as merely inert fat particles, they are now recognized as highly dynamic, mobile organelles required for preventing lipotoxicity and for interacting and cooperating with various organelles. Despite the progress made in understanding the role of LDs, a number of fundamental questions remain unanswered. Effective imaging agents for observing the morphology and dynamic physiological processes of LDs in cells could help address this knowledge gap. Such probes are expected to aid in our understanding of LDs and facilitate the development of new and effective therapeutics. In this review, we have provided a brief introduction to the formation and physiological functions of LDs in an attempt to highlight the importance of these underappreciated organelles. Recent examples of LD-based fluorescent probes are discussed, including the fluorescence phenomenon used in their design. To date, both intramolecular charge transfer (ICT) and aggregation-induced emission (AIE) fluorescence mechanisms have been exploited to create LD probes. However, alternative strategies can be envisioned. We hope the readers will be enlightened as to the importance of these key organelles, will be poised to exploit existing probes to explore various biological applications, and be inspired to create new LD fluorescent sensors that will further our understanding of LDs and their associated physiology. (C) 2020 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据