期刊
COMPLEMENTARY THERAPIES IN MEDICINE
卷 57, 期 -, 页码 -出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ctim.2020.102653
关键词
Nigella sativa; Obesity; Anthropometry; Body composition; Appetite
资金
- Shahid Sadoughi University of Medical Sciences [961020]
- Iran's National Science Foundation (INSF) [96012986]
This study, a first crossover, double-blind, placebo-controlled, randomized clinical trial, demonstrates that N. sativa supplementation has significant positive effects on body mass index, body weight, waist circumference, and negative effects on body fat mass, body fat percent, and visceral fat area. Overall, N. sativa shows promise as a complementary therapy for obesity.
Objectives: Obesity is a global concern which is associated with several complications and disease. Design: Present study is the first crossover, double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the effect of Nigella Sativa (N. sativa) intervention on anthropometric and body composition parameters as well as dietary intake and appetite in a crossover design. Method: Forty-five healthy women with obesity or overweight were randomized into two groups of intervention and placebo, and the study conducted in two 8-week periods of intervention separated by a 4-week washout period. Anthropometric and body composition indices and dietary intake were measured. Also, appetite sensation was evaluated via a standard visual analog scale (VAS) questionnaire. Pkcross procedure was performed for statistical analysis using STATA. Cohen's d effect size was estimated for all outcomes to determine the magnitude of the effects. Results: Supplementation with 2000 mg of N. sativa oil found to have a considerable increment in the measures of body mass index (P < 0.001, Cohen's d = 0.5), body weight (P < 0.001, Cohen's d = 0.6) and waist circumference (P = 0.020, Cohen's d = 0.4) with a medium effect size measure, and a significant decrease in body fat mass (P = 0.019, Cohen's d = 0.2), body fat percent (P < 0.001, Cohen's d = 0.2) and visceral fat area (P = 0.011, Cohen's d = 0.2) with a small effect size measure. Conclusion: The overall improvements in anthropometric and body composition parameters and a significant decrease in appetite represents the beneficial effects of N. sativa supplements in the treatment of obesity. More studies with different dosages, a larger number of participants, and longer intervention duration are recommended to illustrate the exact effects of N. sativa as a complementary therapy for obesity.
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